I few people in this thread have suggested that 10 yards is too close for checking the sights, and that at some longer distance, the gun would be properly sighted in. My thinking is that 10 yards is a common distance for all hangun use, and that even with a longer range zero, the offset at 10 yards should only be an inch or so.
So I spent a few minutes playing with a ballistic calculator. I took the OP at face value that the revolver is really shooting 4" high at 10 yards, which can be approximately translated to 10" high at 25 yards. I made some approximations for sight height over bore and ballistic coefficient.
The ballistic calculator showed that for 425 grains at 1150 fps, 4" high at 10 yards is approximately a 250 yard zero. And with that zero, the round will be 20" high at 50 yards and over 30" high at 100 yards. So pretty much unusable at 50 or 100 yards. And with a 325 grain bullet at slightly higher velocity, the calculations are not drastically different.
For comparison, a 100 yard zero is about .75" high at 10 yards, and a little over 2" high at 25 yards. If someone else wants to check these statistics, I would be perfectly happy to learn about it if I made some mistake. But I have shot handguns a lot at 50 yards, and bit at 100 yards, and all of these numbers seem about right to me.
Assuming that the gun has a replaceable front sight, then changing to a higher front sight should be a pretty straightforward resolution. But as it sits, the gun is distantly off at all practical distances, and I personally would not be satisfied with it.
What ballistic coefficient are you using? This is a handgun cartridge not rifle so would ensure have a low enough BC to confirm accuracy of trajectory. Either way I think most of us agree we would want that POI corrected on this revolver.