Feeding and chambering issues aside, the danger of excessive setback is if it causes an overpressure situation. The worrisome possibility is if the powder detonates rather than burns. Some powders tolerate compression, and burn normally. I'm told that some powders do not. I'm careful not to test this myself.
I'm ignoring the possibility that using a hammer to drive the slide into battery might sufficiently jam the projectile in the case that it can't move forward, giving the gasses nowhere to go but through the primer and toward the shooter's eyes. On the off chance that some readers of the article above have no basic firearms safety training, please DO NOT force a misshapen round to chamber. Discard it properly, in the dud bucket at your range.
The results cited in the article above are consistent with using a powder that does not detonate when compressed. Not all powders share that behavior.