I don't see why it wouldn't. Same diameter case. Similar OAL.
This. There's no reason why they wouldn't work. .300 Blk is just a .223 case necked up to take the .30 cal bullet.
As to not doing one for .300 blk, well, I don't have anything else that eats it, so for the first one I kept it simple. Theoretically you could do any caliber you want, you'd just need to change out the fixed magazine for a caliber appropriate one. Something like a Lancer with a single stack follower would work great for large bore rounds (.458 SOCOM/.450 Bushmaster/.50 Beowulf), though you loose the ability to use the side loaders for any caliber that doesn't use .223 as a parent cartridge. Top loading isn't that bad, and really only slightly more annoying than loading magazines the normal way without a speed loader.
Might do a .300blk one day, but right now I can't really afford to start stockpiling another caliber.