Having owned both ... yes a Big difference and I actually prefer shooting my Glock 10 MM guns over the 22 the heavier mass of the 10 mm slides helps absorb the force of a 40 cal better for me... I sold my Glock 22 and settled on a Glock small sized 29 for my favorite 10mm... I forgot to mention that I have shot 40 cal. thru some of my Glock 10mm guns as well as 10mm bullets .. If you want brutal recoil try a Glock 27 ... it really bites the hand I owned 1 for many years
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