In my experience, people often underestimate both how far bullets actually travel, and how dangerous they are when they get there. This is separate from the difficulty of hitting targets at range.
I have played a bit with CCI Quiet .22 rounds, which are 40 grain soft lead .22 rounds going 720 feet per second at the muzzle. I was surprised to find that they would go through a soft pine 2x4, and they easily penetrate 6 inches into a sand bag. Of course, they have no "stopping power" and will just punch an ice pick wound. But that wound is potentially fatal, and will absolutely require medevac if you are far afield.
So when people say you couldn't get a hit at that range, and even if you did, it wouldn't penetrate a heavy jacket, that is usually only half true. So with centerfire rounds, when you get well past where high velocity bullets have dropped subsonic, then you may really be firing for effect. But if you do get a hit, then damage comparable to a .32 caliber pistol is very plausible.