H110 and W296 are identical in performance (same powder, different label).
They can give high velocities in heavy loads.
Both need magnum primers and a good heavy crimp.
Heavy loads are not for Colt SAA or Ruger New Vaquero or other Colt SAA clones.
Check the manuals for Ruger/ TC load info.
H110 & 296 are both good for these pistols. Unique is also good for around 1050 fps w/ 260g cast bullets, and very accurate.
Above not for Colt's, or clones! Also the new Ruger Vaquero.